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Best choice is Virtualbox from the repos and Windows XP/7 and Virtualbox tools installed. I'm using to have stability with Photoshop CS6 and Skype, using a Windows 7 32bit (home premium).

Using Virtualbox from repos, Fedora will take care of updates for you and be safe and stable.

Wine means lot of headaches if you are willing to waist time instead of being productive.