Cleaning of temporarily files

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There is no need to worry about it in fedora (and in Linux in general). The following directories

/tmp
/var/tmp

will be automatically cleaned up by a dedicated cronjob (/etc/cron.daily/tmpwatch) based on some usage/access criteria. Please just check if your cron service is running and configured to start at boot time.

I would not recommend to cleanup manually those directories because they are used by applications to run correctly so if you by mistake delete some temporary needed files, you might have your application malfunctioning...

For more info on how tmpwatch work just open a terminal and run man tmpwatch