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It depends on the size of your hard disk. But first, make a backup.

Then I'd resize / to make room for a new partition, format it and mount it as /home2, Then copy my files to /home2/myuser. Cleanup the old /home and configure /etc/fstab to mount the new partition as /home.

You can do all that just before reinstalling. You'll fell more confortable next time you install Fedora.