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I think there is not much to speed up on Fedora. GNOME shell is quite slow due to architectural decisions made by its developers. If you want it to speed up, help developing it. If you have GNOME shell running for a long time (many hours or even days) you may want to logoff and logon to restart it in case it does leak memory.

You may clear caches by deleting files in ~/.cache/ which is totally safe as long as the application using that cache is not running. I doubt that this will help at all to speed up your computer. It only will if your disk is quite full.

Temporary files are often created in /tmp, /run or /run/user/[uid]. These folders will be thrown away on reboot so there is nothing you need to do.

If you want more details you probably should describe a specific case of what to speed up.